| With the world’s highest cooling tower (220 m) which is being built as the engineering background, the wind tunnel tests of pressure measurement under single tower condition and six typical group towers combinations were conducted. The influence laws of static, dynamic and extreme interference effects of different typical four towers combinations were discussed. The mathematical statistics method and frequency spectrum method were used for analyzing different influencing factors and mechanisms. Then, the formulas of interference factors for typical four towers combinations considering wind directions were given. Finally, based on comprehensive assessment of the interference effects of overall wind loads, the best scheme for the arrangement of the four towers in a row was proposed, which followed the arrangements in oblique L shaped pattern, L shaped pattern, rhombic pattern, and rectangular pattern successively. A strong linear correlation was found to exist between the characteristic angle α and the maximum FE of five typical four tower arrangements.