Based on vehicle with brake by wire system (BBW), this paper proposed a new yaw stability optimized control strategy. Two degrees of freedom vehicle model was used as reference model, and proportional integral (PI) control algorithm was used to derive the additional yaw moment. According to the additional yaw moment and the steering wheel angle, the driver’s intention and the actual driving characteristics of vehicle were recognized. This paper distributed the additional yaw moment to every wheel based on the method combining the Pseudo Inverse method and mathematical programming approach. Within brake by wire system, the master cylinder fixed frequency pressure-regulating method was used to follow the target wheel cylinder pressure. The results of hardware-in-loop (HIL) test show that this control strategy can ensure the yaw stability of vehicle effectively on the road surface with high or low adhesion coefficient.