Quality function deployment(QFD) was employed to get customers key function requirements on the information system, and with the help of failure mode and effect analysis(FMEA), potential failure modes and possible risk severity prediction on the process of product life stages in the early development of information systems could be found. The methods met the interests of customers and it maximized the enterprise efficiency at the same time. The similarity and complementarity between QFD and FMEA were analyzed by building a joint quality management model based on QFD and FMEA. A case study was made as well on the OA information system on the basis of the application of the joint model, which improved the information system, and the method was proved feasible and practible.