| By taking two simply supported box girder bridges of 30 m as example, a systematic dynamic simulation model of vehicle track bridge was established, with a consideration of the coupling mechanism of multi layer vibration isolation system. The finite element model(FEM) was verified by a set of field tests. Good agreement between measurement and predicted results proved the effectiveness and accuracy of the model. With the validated simulation model, the effect of resilient parameters on the dynamic response of vehicle, track, slab, bridge wing plate, web plate, bottom plate and bridge pier, was obtained. Finally, parameter matching principle was presented. The results indicate that an optimized elastic parameters matching design of viaducts may improve the isolation efficiency for the vibration environment along railway lines, and ameliorate the dynamic properties of each substructure of vehicle rail bridge systems.