A computer simulation was carried out to study the fire safety distance between color steel polystyrene sandwich panel houses based on the existing experimental data. The comparison between the simulation and experimental results shows that, for the worst case, the average relative error of the maximum heat radiation intensity is 8.77%，and the maximum temperature is 7.71%, which verifies the simulation method. A subsequent simulation study focused on the effect of different wind speeds to the development of panel house fire based on the former mode，the fire safety distance formulas were obtained by the regression analysis. With good correlations, the formulas can be promoted and they can be further used as a reference for the design and the calculation of the fire safety distance between sandwich panel houses.